I have killed a ton of coyotes with a 22 mag on the run. I used to hound hunt evry day all winter long. It works great out to 150 yards. I have killed probably 20 or so with a 22 lr. Mainly when the dogs had then bayed up. However. I have killed a few on the run with cci stingers. Inside of 100 yards a body shot WILL end up in a track job. A head shot is perfect.